Syllabus Application
BIO 301
Introduction to Molecular Biology
Faculty
Faculty of Engineering and Natural Sciences
Semester
Spring 2025-2026
Course
BIO 301 -
Introduction to Molecular Biology
Time/Place
Time
Week Day
Place
Date
14:40-16:30
Tue
FENS-G029
Feb 16-May 22, 2026
12:40-13:30
Thu
FENS-G029
Feb 16-May 22, 2026
Level of course
Undergraduate
Course Credits
SU Credit:4, ECTS:7, Basic:7
Prerequisites
BIO 321
Corequisites
BIO 301L
Course Type
Lecture
Instructor(s) Information
Duygu Kuzuoğlu Öztürk
Course Information
Catalog Course Description
Introduction to Molecular Biology is a detailed introduction to basic mechanisms of molecular biology and genetics. Starting from genomic information and genome organization, DNA structure, packaging to chromosomes, replication of genetic material and its fidelity, mechanisms to repair and recombination of DNA will be discussed in the lecture. RNA structure, mechanisms of DNA transcription to RNA, transcriptional control mechanisms and transcription factors will be studied in detail. RNA to protein translation mechanisms and ribosome structure will be dissected. Protein stability, protein degradation echanisms, role of miRNAs and RNA stability on gene expression will be discussed. A general introduction to programmed cell death mechanims will be presented.The lab course is practical course on principle techniques for production of recombinant proteins in bacteria and animal cells. Lab work will involve utilisation of molecular cloning techniques to produce a particular gene product. Recombinant plasmids carrying either single gene or that for a fusion protein will be constructed and used to transform E. coli, and the gene products will be isolated and characterized.
Course Learning Outcomes:
| 1. | To successfully complete Intro. to Molecular Biology (BIO 301) students are expected to; Gain a clear knowledge about cell cycle and its regulation. |
|---|---|
| 2. | Have an insight of gene and chromosme structure. |
| 3. | Have a general idea about chromosome remodelling. |
| 4. | Define the stages of DNA replication in eukaryotes and prokaryotes. |
| 5. | Define the types of mutations, DNA damage and repair mechanisms. |
| 6. | Clearly define the stages of transcription and translation. |
| 7. | Have a general idea about recombinant protein production via molecular cloning. |
Course Objective
To teach fundamentals of traditional and modern concepts genetics.
Sustainable Development Goals (SDGs) Related to This Course:
| Good Health and Well-being | |
| Responsible Consumption and Production | |
| Life Below Water | |
| Life On Land |
Course Materials
Resources:
Main Book:
• Molecular Biology of the Gene, Seventh Edition, Pearson
J. D. Watson, T. A. Baker, S. P. Bell, A. Gann, M. Levine, R. Losick ISBN-13: 9780321762436
Additional Sources:
• Molecular Biology Principles of Genome Function
N. Craig, R. Green, C. Greider, G. Storz, C. Wolberger, O. Cohen-Fix ISBN-13: 978-0199658572
• Molecular Biology of the Cell
B. Alberts, A. D. Johnson, J. Lewis, D. Morgan, M. Raff, K. Roberts, P. Walter ISBN-13: 978-0815344322
• Review articles
• Research articles
• Molecular Biology of the Gene, Seventh Edition, Pearson
J. D. Watson, T. A. Baker, S. P. Bell, A. Gann, M. Levine, R. Losick ISBN-13: 9780321762436
Additional Sources:
• Molecular Biology Principles of Genome Function
N. Craig, R. Green, C. Greider, G. Storz, C. Wolberger, O. Cohen-Fix ISBN-13: 978-0199658572
• Molecular Biology of the Cell
B. Alberts, A. D. Johnson, J. Lewis, D. Morgan, M. Raff, K. Roberts, P. Walter ISBN-13: 978-0815344322
• Review articles
• Research articles
Technology Requirements:
All the students should have access to a laptop