Syllabus Application
Tissue Engineering
BIO 421
Faculty:
Faculty of Engineering and Natural Sciences
Semester:
Fall 2025-2026
Course:
Tissue Engineering - BIO 421
Classroom:
FENS-G025,FENS-L030
Level of course:
Undergraduate
Course Credits:
SU Credit:3.000, ECTS:6, Engineering:6
Prerequisites:
BIO 301 and BIO 332
Corequisites:
BIO 421L
Course Type:
Lecture
Instructor(s) Information
Sibel Çetinel
- Email: cetinel@sabanciuniv.edu
Course Information
Catalog Course Description
Tissue engineering combines the skills of engineering and knowledge of principle biology to generate, restore and replace damaged tissues and organs. To engineer living tissues mimicking conditions in living organism is essential. Therefore, tissue engineering is considered a biomedical engineering discipline and a potential alternative to tissue and organ transplantation. This course is built on three main pillars of tissue engineering: cells, scaffolds, and growth factors. Initially stem cells and differentiation is discussed as well as cell-based tissue engineering applications. Then design and characterization of biomaterials and nanomaterials as tissue scaffolds are covered. Here, various bio-fabrication techniques including 3D bioprinting are detailed. This course also covers the interaction with biomaterial surface, mechanical loading, biologic regulators, and culture conditions. Finally, examples of tissue engineering- based procedures that can alleviate specific diseases and clinical translation of regenerative therapies are analyzed as case studies with student presentations. This course also contains a laboratory session. At this session students will learn to handle mammalian cell cultures, prepare hydrogel and polymer scaffolds, perform tissue culture and characterization.
Course Learning Outcomes:
| 1. | Describe the significance, status, and future potential of tissue engineering, |
|---|---|
| 2. | Explain the challenges of tissue engineering of different (individual) tissues, |
| 3. | Explain the biomaterial selection, design, and characterization criteria for scaffold generation, |
| 4. | Explain the selection, source, and handling of cells for tissue engineering applications, |
| 5. | Explain the selection of bio-fabrication method for different (individual) tissues, |
| 6. | Describe the challenges of in vivo transplantation and clinical translation of tissue engineered systems, |
| 7. | Manage to identify the scientific problem and formulate the solution, |
| 8. | Present a literature study, discuss, and deduct the scientific information. |
| 9. | Perform mammalian cell culture on tissue scaffolds. |
Course Objective
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Course Materials
Resources:
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Technology Requirements:
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